fusion proteins

CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder

Cyclin-dependent kinase like-5 (CDKL5) disorder is a rare neurodevelopmental disease caused by mutations in the CDKL5 gene. The consequent misexpression of the CDKL5 protein in the nervous system leads to a severe phenotype characterized by …